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CS-W001157 4
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(αR,βR)-α,β-Diphenyl-1-piperidineethanamine

  • CAS No. 1262516-53-9

  • Cat. No. CS-0093053
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(αR,βR)-α,β-Diphenyl-1-piperidineethanamine|CS-0093053

Structure of 1262516-53-9

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General Information

  • CAS No. 1262516-53-9
  • Cat. No. CS-0093053
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₉H₂₄N₂
  • Molecular Weight 280.41
  • Synonym(s) (1R,2R)-1,2-diphenyl-2-(piperidin-1-yl)ethanamine
  • SMILES N[C@H](C1=CC=CC=C1)[C@@H](C2=CC=CC=C2)N3CCCCC3

Description

This chiral piperidine derivative features a rigid, sterically defined scaffold with two aryl substituents positioned at the α and β carbons, enabling precise stereocontrol in asymmetric synthesis. The (αR,βR) configuration imparts high enantioselectivity in catalytic transformations, particularly in transition-metal-mediated C–C bond formation. Its bench-stable, moisture-tolerant nature simplifies handling under standard conditions.

Application

(αR,βR)-α,β-Diphenyl-1-piperidineethanamine serves as a chiral building block for the synthesis of bioactive molecules, particularly in medicinal chemistry. Its rigid, stereodefined structure enables selective functionalization and facilitates the construction of complex heterocyclic scaffolds. The molecule exhibits good bench stability and compatibility with standard coupling reactions, making it suitable for modular synthesis workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   29.26
  • LogP   3.9136
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   4

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