(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-cyclopentylpropanoic acid

Name: (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-cyclopentylpropanoic acid
Brand: ChemScene
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CAS No. 1262802-59-4
Cat. No. CS-0036237
Purity≥98%
MDL No.None

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(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-cyclopentylpropanoic acid|CS-0036237

Structure of 1262802-59-4

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Description

(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-cyclopentylpropanoic acid is a chiral building block featuring a fluorenylmethoxycarbonyl (Fmoc) protecting group and a cyclopentyl-substituted aliphatic chain. This configuration enables selective incorporation into peptide sequences under standard coupling conditions, offering enhanced solubility and stability during solid-phase synthesis.

Application

(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-cyclopentylpropanoic acid serves as a valuable chiral building block for peptide synthesis, offering enhanced solubility and stability during SPPS. The Fmoc group enables efficient deprotection under mild basic conditions, while the cyclopentylproline-like structure provides conformational restraint useful in bioactive peptide design. Its bench-stable nature and compatibility with standard coupling protocols facilitate reliable incorporation into complex sequences.

General Information

CAS No. 1262802-59-4
Cat. No. CS-0036237
Purity ≥98%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₃H₂₅NO₄
Molecular Weight 379.45
Synonym(s) N-α-(9-Fluorenylmethoxycarbonyl)-β-cyclopentyl-D-alanine
SMILES C1CCC(C1)C[C@H](C(=O)O)NC(=O)OCC2C3=C(C=CC=C3)C4=C2C=CC=C4

Computational Chemistry Data

TPSA 75.63
LogP 4.5586
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 6

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Life Science Amino Acids and their Derivatives Alanine and derivatives

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

Key Words

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(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-cyclopentylpropanoic acid

CAS No. 1262802-59-4

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