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Structure of 1263180-22-8
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tert-Butyl (3,3-difluoropiperidin-4-yl)carbamate is a bench-stable, moisture-tolerant building block featuring a sterically hindered piperidine core with dual fluorine atoms at the 3,3-positions. This configuration enhances metabolic stability and modulates electron density, enabling efficient incorporation into bioactive molecules. The carbamate group facilitates straightforward deprotection under mild acidic conditions, streamlining synthetic workflows in medicinal chemistry and peptide conjugation.
tert-Butyl (3,3-difluoropiperidin-4-yl)carbamate serves as a stable, bench-ready building block for the synthesis of fluorinated piperidine scaffolds. The difluoro substitution at C3 enhances metabolic stability and modulates basicity, while the tert-butoxycarbonyl (Boc) group enables straightforward deprotection under mild acidic conditions. It functions effectively in standard coupling reactions, enabling access to diverse bioactive molecules through iterative functionalization.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: