2-Bromo-6-methylpyridin-3-amine

Name: 2-Bromo-6-methylpyridin-3-amine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 126325-53-9
Cat. No. CS-0007528
Purity≥96%
MDL No.MFCD03095078

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2-Bromo-6-methylpyridin-3-amine|CS-0007528

Structure of 126325-53-9

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Description

2-Bromo-6-methylpyridin-3-amine features a bromine substituent at the 2-position and a methyl group at the 6-position, creating a sterically hindered, electron-deficient pyridine scaffold. This combination enables selective coupling reactions in late-stage functionalization, particularly in transition metal-catalyzed cross-couplings. The amine functionality provides a reactive handle for conjugation, facilitating integration into complex molecular architectures.

Application

2-Bromo-6-methylpyridin-3-amine serves as a versatile building block in heterocyclic synthesis, enabling palladium-catalyzed cross-coupling reactions due to its reactive bromine and amine functionalities. The methyl group enhances electronic modulation and metabolic stability in pharmaceutical scaffolds. Its bench-stable nature and compatibility with standard coupling protocols facilitate efficient access to complex pyridine-based architectures used in medicinal chemistry and agrochemical development.

General Information

CAS No. 126325-53-9
Cat. No. CS-0007528
Purity ≥96%
MDL No. MFCD03095078
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₇BrN₂
Molecular Weight 187.04
Synonym(s) 3-Amino-2-bromo-6-methylpyridine
SMILES NC1=CC=C(C)N=C1Br

Computational Chemistry Data

TPSA 38.91
LogP 1.73472
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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2-Bromo-6-methylpyridin-3-amine

CAS No. 126325-53-9

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