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Structure of 1266105-16-1
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4,6-Dichloro-2-iodopyrimidine offers a highly reactive trifunctional pyrimidine scaffold featuring complementary halogen sites for sequential cross-coupling. The iodine moiety enables palladium-catalyzed coupling under mild conditions, while the chloro groups facilitate further functionalization via nucleophilic substitution or metal-mediated transformations. This reactivity profile supports rapid diversification in medicinal chemistry and materials synthesis.
4,6-Dichloro-2-iodopyrimidine serves as a versatile building block for C–H functionalization and cross-coupling reactions in medicinal chemistry. The dichloro substitution pattern enables selective late-stage derivatization, while the iodine moiety facilitates palladium-catalyzed coupling with arylboranes, amines, and thiols. Its bench-stable nature and compatibility with diverse reaction conditions make it ideal for constructing substituted pyrimidine scaffolds commonly found in kinase inhibitors and antiviral agents.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: