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CS-W001157 4
Total: USD 88.00

2-Amino-3,5-difluorobenzoic acid

  • CAS No. 126674-78-0

  • Cat. No. CS-W018686
  • Purity≥97%
  • MDL No.MFCD01569541
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

2-Amino-3,5-difluorobenzoic acid|CS-W018686

Structure of 126674-78-0

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Description

2-Amino-3,5-difluorobenzoic acid delivers a trifunctional scaffold featuring an electron-rich amine, two fluorine substituents at meta positions, and a carboxylic acid for conjugation. This combination enables direct incorporation into bioconjugation workflows, peptide synthesis, and medicinal chemistry campaigns requiring enhanced metabolic stability and targeted electronic modulation.

Application

2-Amino-3,5-difluorobenzoic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of fluorinated heterocycles and bioactive scaffolds. Its ortho-amino and difluorinated aromatic core provides enhanced metabolic stability and modulated electronic properties. The carboxylic acid group facilitates direct coupling reactions, while the amino functionality supports derivatization via acylation, sulfonylation, or diazotization. Bench-stable and readily purified by recrystallization, it functions effectively in standard peptide coupling and transition-metal-catalyzed transformations.

General Information

  • CAS No. 126674-78-0
  • Cat. No. CS-W018686
  • Purity ≥97%
  • MDL No. MFCD01569541
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅F₂NO₂
  • Molecular Weight None
  • Synonym(s) benzoic acid, 2-amino-3,5-difluoro-
  • SMILES NC1=C(C(=O)O)C=C(C=C1F)F

Computational Chemistry Data

  • TPSA   63.32
  • LogP   1.2452
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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