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CS-W001157 4
Total: USD 88.00

4-Chloropyrazolo[1,5-a]pyridine-7-carbonitrile

  • CAS No. 1268520-74-6

  • Cat. No. CS-0050887
  • Purity≥95%
  • MDL No.None
  • HazMat Fee +

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    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4-Chloropyrazolo[1,5-a]pyridine-7-carbonitrile|CS-0050887

Structure of 1268520-74-6

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Description

4-Chloropyrazolo[1,5-a]pyridine-7-carbonitrile features a fused heterocyclic core with complementary electron-withdrawing groups: a chlorine atom at the 4-position and a nitrile function at the 7-position. This combination enhances electrophilicity and facilitates coupling reactions in medicinal chemistry applications. The scaffold exhibits excellent stability under standard bench conditions and integrates readily into bioactive molecule architectures.

Application

4-Chloropyrazolo[1,5-a]pyridine-7-carbonitrile serves as a versatile heterocyclic building block for medicinal chemistry and catalytic synthesis. Its chloro and cyano groups enable directed metalation, Suzuki-Miyaura coupling, and nucleophilic substitution, facilitating the construction of complex pyrazolopyridine scaffolds. The molecule exhibits excellent bench stability and compatibility with standard purification methods, making it well-suited for scalable synthesis and library generation in drug discovery workflows.

General Information

  • CAS No. 1268520-74-6
  • Cat. No. CS-0050887
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₄ClN₃
  • Molecular Weight 177.59
  • Synonym(s) None
  • SMILES ClC1=CC=C(C#N)N2N=CC=C12

Computational Chemistry Data

  • TPSA   41.09
  • LogP   1.85938
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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