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1-Ethynylcyclopropan-1-amine hydrochloride

  • CAS No. 1268810-17-8

  • Cat. No. CS-B0936
  • Molecule weight117.58
  • Purity≥95%
  • MDL No.MFCD28404680

*For research and further manufacturing use only, not for direct human use.

1-Ethynylcyclopropan-1-amine hydrochloride|CS-B0936

Structure of 1268810-17-8

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General Information

  • CAS No. 1268810-17-8
  • Cat. No. CS-B0936
  • Purity ≥95%
  • MDL No. MFCD28404680
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₈ClN
  • Molecular Weight 117.58
  • Synonym(s) 1-Amino-1-ethynylcyclopropane hydrochloride; 1-Ethynylcyclopropanamine hydrochloride
  • SMILES NC1(C#C)CC1.[H]Cl

Description

1-Ethynylcyclopropan-1-amine hydrochloride features a strained cyclopropyl ring fused to an ethynyl group and a protonated amine, delivering high reactivity in click chemistry. This bench-stable, moisture-tolerant derivative enables efficient coupling under mild conditions, facilitating rapid access to functionalized scaffolds in medicinal chemistry and chemical biology applications.

Application

1-Ethynylcyclopropan-1-amine hydrochloride serves as a versatile building block for the synthesis of bioactive heterocycles and functionalized alkynes. Its cyclopropyl scaffold imparts structural rigidity, while the terminal alkyne and amine functionalities enable diverse coupling reactions, including copper-catalyzed azide-alkyne cycloadditions (CuAAC) and nucleophilic substitutions. The hydrochloride salt enhances bench stability and facilitates purification, making it suitable for medicinal chemistry campaigns and API intermediate development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P233-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   0.5327
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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