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Structure of 1269493-45-9
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5-Bromo-2-fluoro-4-methylbenzonitrile features a trifunctional aromatic core with bromine, fluorine, and methyl groups positioned for orthogonal reactivity. The nitrile group enables direct coupling or conversion to amides, while the electron-deficient ring supports palladium-catalyzed cross-coupling. This bench-stable intermediate integrates cleanly into complex molecular architectures.
5-Bromo-2-fluoro-4-methylbenzonitrile serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient construction of substituted heterocycles via palladium-catalyzed cross-coupling. The molecule exhibits excellent bench stability, tolerates diverse functional groups, and facilitates straightforward purification due to its defined polarity and crystalline nature. Its orthogonal reactivity profile—where bromine undergoes selective coupling while fluorine remains inert—supports modular assembly of complex scaffolds in multi-step sequences.
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GHS No : GHS06
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Signal Word : Danger
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UN#: 3439
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H302+H312-H315-H319-H331-H335
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Precautionary Statements : P264-P270-P330-P405-P501
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Lot numbers can be found on the outside label of a product: