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CS-W001157 4
Total: USD 88.00

5-Bromo-2-(piperidin-2-yl)pyridine

  • CAS No. 1270356-25-6

  • Cat. No. CS-0526975
  • Purity≥98%
  • MDL No.None
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

5-Bromo-2-(piperidin-2-yl)pyridine|CS-0526975

Structure of 1270356-25-6

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Description

5-Bromo-2-(piperidin-2-yl)pyridine features a brominated pyridine core paired with a piperidinyl substituent, enabling efficient coupling in cross-coupling reactions. The electron-deficient aromatic ring facilitates transition-metal catalysis, while the pendant piperidine offers solubility and coordination potential. This compound serves as a key building block in medicinal chemistry for targeted heterocyclic scaffolds.

Application

5-Bromo-2-(piperidin-2-yl)pyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions for the construction of biaryl and heteroaryl scaffolds. The bromide functionality offers high reactivity in Suzuki, Stille, and Negishi couplings, while the piperidinyl group provides a basic nitrogen for metal coordination and potential hydrogen bonding in target molecules. Bench-stable and readily purified by column chromatography, it facilitates efficient synthesis of complex pharmaceutical intermediates.

General Information

  • CAS No. 1270356-25-6
  • Cat. No. CS-0526975
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₃BrN₂
  • Molecular Weight 241.13
  • Synonym(s) 5-Bromo-2-(2-piperidinyl)pyridine
  • SMILES BrC1=CN=C(C2NCCCC2)C=C1

Computational Chemistry Data

  • TPSA   24.92
  • LogP   2.6587
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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