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Structure of 881040-24-0
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5-(Piperidin-4-yl)-1,3,4-thiadiazol-2-amine features a rigid thiadiazole core fused with a piperidine ring, delivering enhanced solubility and metabolic stability. This scaffold integrates a primary amine at the 2-position, enabling facile conjugation in medicinal chemistry applications. The molecule exhibits favorable hydrogen-bonding capacity and electron-rich character, supporting strong target engagement in kinase inhibitor design and chemical biology probes.
5-(Piperidin-4-yl)-1,3,4-thiadiazol-2-amine serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to bioactive scaffolds. Its piperidine moiety enhances solubility and pharmacokinetic properties, while the 1,3,4-thiadiazole core provides structural rigidity and hydrogen-bonding capability. The amine functionality facilitates straightforward derivatization via alkylation, acylation, or coupling reactions, supporting rapid library synthesis. This compound exhibits good bench stability and is compatible with standard purification methods, making it well-suited for high-throughput screening and lead optimization workflows.
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GHS No : GHS05
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Signal Word : Danger
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UN#: 3259
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H314
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: