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CS-W001157 4
Total: USD 88.00

1-Isopropylpiperidin-4-amine

  • CAS No. 127285-08-9

  • Cat. No. CS-W021344
  • Molecule weight142.24
  • Purity≥98%
  • MDL No.MFCD03411606

*For research and further manufacturing use only, not for direct human use.

1-Isopropylpiperidin-4-amine|CS-W021344

Structure of 127285-08-9

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General Information

  • CAS No. 127285-08-9
  • Cat. No. CS-W021344
  • Purity ≥98%
  • MDL No. MFCD03411606
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₈N₂
  • Molecular Weight 142.24
  • Synonym(s) (1-isopropyl-4-piperidyl)amine
  • SMILES NC1CCN(C(C)C)CC1

Description

1-Isopropylpiperidin-4-amine features a sterically hindered piperidine core with a primary amine at the 4-position and a branched isopropyl group attached to nitrogen. This configuration imparts enhanced solubility and nucleophilicity, enabling efficient incorporation into complex molecular architectures. The molecule exhibits bench-stable handling under standard conditions and serves as a key building block in medicinal chemistry.

Application

1-Isopropylpiperidin-4-amine serves as a versatile nitrogen-containing building block in medicinal chemistry, enabling the construction of diverse heterocyclic scaffolds. Its tertiary amine functionality offers favorable solubility and basicity profiles, while the piperidinyl core provides structural rigidity and metabolic stability. The molecule exhibits excellent bench stability and compatibility with standard functional group transformations, facilitating efficient synthesis of drug candidates and intermediates in API development workflows.

Synthesis

  • Route1
    • tert-butyl N-(1-propan-2-ylpiperidin-4-yl)carbamate|CS-0207791
      534595-37-4
    • ~99%
    • In-stock
      1-Isopropylpiperidin-4-amine|CS-W021344
      127285-08-9

    References

    • Nazare, Marc; Will, David W.; Matter, Hans; Schreuder, Herman; Ritter, Kurt; Urmann, Matthias; Essrich, Melanie; Bauer, Armin; Wagner, Michael; Czech, Joerg; Lorenz, Martin; Laux, Volker; Wehner, Volkmar Journal of Medicinal Chemistry, 2005 , vol. 48, # 14 p. 4511 - 4525
  • Route2
    • null|null
      609804-23-1
    • ~%
    • In-stock
      1-Isopropylpiperidin-4-amine|CS-W021344
      127285-08-9

    References

    • EP1489078 A1, ; Page 130 ; EP 1489078 A1
  • Route3

    References

    • Journal of Medicinal Chemistry, , vol. 48, # 14 p. 4511 - 4525

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS05
Signal Word : Danger
UN#: 2920
Class : 8,3
Packing Group : Ⅱ
Hazard Statements : H226-H314
Precautionary Statements : P210-P233-P240-P241-P242-P243-P260-P264-P280-P301+P330+P331-P304+P340-P363-P370+P378-P405-P501

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Computational Chemistry Data

  • TPSA   29.26
  • LogP   0.8179
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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