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CS-W001157 4
Total: USD 88.00

cis-(1-Benzylazetidine-2,4-diyl)dimethanol

  • CAS No. 127310-66-1

  • Cat. No. CS-0035527
  • Purity≥96%
  • MDL No.MFCD28991841
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

cis-(1-Benzylazetidine-2,4-diyl)dimethanol|CS-0035527

Structure of 127310-66-1

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Description

cis-(1-Benzylazetidine-2,4-diyl)dimethanol features a rigid, cis-configured azetidine core with two pendant hydroxymethyl groups, enabling precise spatial control in molecular scaffolding. The benzyl substituent enhances solubility and provides a handle for further derivatization, while the diol functionality supports hydrogen bonding and integration into complex synthetic intermediates.

Application

cis-(1-Benzylazetidine-2,4-diyl)dimethanol serves as a versatile chiral building block for the synthesis of nitrogen-containing heterocycles and bioactive scaffolds. Its cis-configured azetidine core exhibits enhanced stability and predictable stereochemistry, enabling efficient functionalization at both C2 and C4 positions. The pendant benzyl group provides orthogonal reactivity, while the two primary alcohol functionalities facilitate conjugation, derivatization, or protection strategies in multi-step syntheses. This compound functions reliably in standard coupling, cyclization, and modification protocols common to medicinal chemistry and process development workflows.

General Information

  • CAS No. 127310-66-1
  • Cat. No. CS-0035527
  • Purity ≥96%
  • MDL No. MFCD28991841
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₇NO₂
  • Molecular Weight 207.27
  • Synonym(s) rel-(2R,4S)-1-(Phenylmethyl)-2,4-azetidinedimethanol
  • SMILES OC[C@@H]1N(CC2=CC=CC=C2)[C@H](CO)C1

Computational Chemistry Data

  • TPSA   43.7
  • LogP   0.6141
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   4

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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