Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

cis-(1-Benzylazetidine-2,4-diyl)dimethanol

  • CAS No. 127310-66-1

  • Cat. No. CS-0035527
  • Purity≥96%
  • MDL No.MFCD28991841

*For research and further manufacturing use only, not for direct human use.

cis-(1-Benzylazetidine-2,4-diyl)dimethanol|CS-0035527

Structure of 127310-66-1

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 127310-66-1
  • Cat. No. CS-0035527
  • Purity ≥96%
  • MDL No. MFCD28991841
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₇NO₂
  • Molecular Weight 207.27
  • Synonym(s) rel-(2R,4S)-1-(Phenylmethyl)-2,4-azetidinedimethanol
  • SMILES OC[C@@H]1N(CC2=CC=CC=C2)[C@H](CO)C1

Description

cis-(1-Benzylazetidine-2,4-diyl)dimethanol features a rigid, cis-configured azetidine core with two pendant hydroxymethyl groups, enabling precise spatial control in molecular scaffolding. The benzyl substituent enhances solubility and provides a handle for further derivatization, while the diol functionality supports hydrogen bonding and integration into complex synthetic intermediates.

Application

cis-(1-Benzylazetidine-2,4-diyl)dimethanol serves as a versatile chiral building block for the synthesis of nitrogen-containing heterocycles and bioactive scaffolds. Its cis-configured azetidine core exhibits enhanced stability and predictable stereochemistry, enabling efficient functionalization at both C2 and C4 positions. The pendant benzyl group provides orthogonal reactivity, while the two primary alcohol functionalities facilitate conjugation, derivatization, or protection strategies in multi-step syntheses. This compound functions reliably in standard coupling, cyclization, and modification protocols common to medicinal chemistry and process development workflows.

Synthesis

  • Route1
    • null|null
      100-46-9
    • ~%
    • In-stock
      cis-(1-Benzylazetidine-2,4-diyl)dimethanol|CS-0035527
      127310-66-1

    References

    • Guanti, Giuseppe; Riva, Renata Tetrahedron Asymmetry, 2001 , vol. 12, # 4 p. 605 - 618
  • Route2
    • null|null
      2873-74-7
    • ~%
    • In-stock
      cis-(1-Benzylazetidine-2,4-diyl)dimethanol|CS-0035527
      127310-66-1

    References

    • TARGACEPT, INC.; JORDAN, Kristen G.; LETCHWORTH, Sharon Rae Patent: WO2014/11863 A1, 2014 ;
  • Route3
    • null|null
      108-55-4
    • ~%
    • In-stock
      cis-(1-Benzylazetidine-2,4-diyl)dimethanol|CS-0035527
      127310-66-1

    References

    • Ding, Derong; Nickell, Justin R.; Deaciuc, Agripina G.; Penthala, Narsimha Reddy; Dwoskin, Linda P.; Crooks, Peter A. Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 21 p. 6771 - 6777

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   43.7
  • LogP   0.6141
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   4

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 127310-66-1 sigma127310-66-1 manufacturer127310-66-1 price127310-66-1 structure127310-66-1 SDSbuy 127310-66-1127310-66-1 supplier127310-66-1 uses127310-66-1 molecular weightprice of 127310-66-1127310-66-1 chemical name formula of 127310-66-1
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label