(R)-1-(3-(Trifluoromethyl)phenyl)ethan-1-amine

Name: (R)-1-(3-(Trifluoromethyl)phenyl)ethan-1-amine
Brand: ChemScene
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CAS No. 127852-30-6
Cat. No. CS-0000150
Molecule weight189.18
Purity≥97%
MDL No.MFCD03093005

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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(R)-1-(3-(Trifluoromethyl)phenyl)ethan-1-amine|CS-0000150

Structure of 127852-30-6

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General Information

CAS No. 127852-30-6
Cat. No. CS-0000150
Purity ≥97%
MDL No. MFCD03093005
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₉H₁₀F₃N
Molecular Weight 189.18
Synonym(s) (1R)-1-[3-(trifluoromethyl)phenyl]ethanamine
SMILES N[C@@H](C1=CC=CC(C(F)(F)F)=C1)C

Description

This chiral amine features a (R)-configured stereocenter adjacent to a trifluoromethyl-substituted phenyl group, delivering enhanced electron-withdrawing character and improved metabolic stability. The trifluoromethyl moiety imparts high lipophilicity and resistance to oxidative degradation, enabling robust incorporation into bioactive molecules. This bench-stable compound serves as a key building block in asymmetric synthesis, particularly for pharmaceutical intermediates requiring defined stereochemistry and fluorinated aromatic functionality.

Application

(R)-1-(3-(Trifluoromethyl)phenyl)ethan-1-amine serves as a valuable chiral building block in medicinal chemistry, enabling the synthesis of asymmetric pharmaceutical intermediates. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the enantiomerically pure amine functionality facilitates selective coupling reactions and stereoselective transformations. The compound exhibits good bench stability and is compatible with standard purification protocols, making it suitable for scale-up applications in API development.

Synthesis

Route1
- 437762-10-2
- 444643-04-3
- ~%
- In-stock
  
  127852-21-5
- In-stock
  
  127852-30-6
References
- US6797842 B2, ; Page column 23 ;
Route2
- In-stock
  
  349-76-8
- ~%
- In-stock
  
  127852-30-6
References
- Journal of the American Chemical Society, , vol. 112, # 15 p. 5741 - 5747

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS05
Signal Word : Danger	UN#: 2735
Class : 8	Packing Group : Ⅲ
Hazard Statements : H302-H318
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 26.02
LogP 2.7251
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

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(R)-1-(3-(Trifluoromethyl)phenyl)ethan-1-amine

CAS No. 127852-30-6

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