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CS-W001157 4
Total: USD 88.00

(R)-1-(3-(Trifluoromethyl)phenyl)ethan-1-amine

  • CAS No. 127852-30-6

  • Cat. No. CS-0000150
  • Purity≥97%
  • MDL No.MFCD03093005
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

(R)-1-(3-(Trifluoromethyl)phenyl)ethan-1-amine|CS-0000150

Structure of 127852-30-6

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Description

This chiral amine features a (R)-configured stereocenter adjacent to a trifluoromethyl-substituted phenyl group, delivering enhanced electron-withdrawing character and improved metabolic stability. The trifluoromethyl moiety imparts high lipophilicity and resistance to oxidative degradation, enabling robust incorporation into bioactive molecules. This bench-stable compound serves as a key building block in asymmetric synthesis, particularly for pharmaceutical intermediates requiring defined stereochemistry and fluorinated aromatic functionality.

Application

(R)-1-(3-(Trifluoromethyl)phenyl)ethan-1-amine serves as a valuable chiral building block in medicinal chemistry, enabling the synthesis of asymmetric pharmaceutical intermediates. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the enantiomerically pure amine functionality facilitates selective coupling reactions and stereoselective transformations. The compound exhibits good bench stability and is compatible with standard purification protocols, making it suitable for scale-up applications in API development.

General Information

  • CAS No. 127852-30-6
  • Cat. No. CS-0000150
  • Purity ≥97%
  • MDL No. MFCD03093005
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₀F₃N
  • Molecular Weight 189.18
  • Synonym(s) (1R)-1-[3-(trifluoromethyl)phenyl]ethanamine
  • SMILES N[C@@H](C1=CC=CC(C(F)(F)F)=C1)C

Computational Chemistry Data

  • TPSA   26.02
  • LogP   2.7251
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 2735
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H318
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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