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Structure of 127852-30-6
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This chiral amine features a (R)-configured stereocenter adjacent to a trifluoromethyl-substituted phenyl group, delivering enhanced electron-withdrawing character and improved metabolic stability. The trifluoromethyl moiety imparts high lipophilicity and resistance to oxidative degradation, enabling robust incorporation into bioactive molecules. This bench-stable compound serves as a key building block in asymmetric synthesis, particularly for pharmaceutical intermediates requiring defined stereochemistry and fluorinated aromatic functionality.
(R)-1-(3-(Trifluoromethyl)phenyl)ethan-1-amine serves as a valuable chiral building block in medicinal chemistry, enabling the synthesis of asymmetric pharmaceutical intermediates. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the enantiomerically pure amine functionality facilitates selective coupling reactions and stereoselective transformations. The compound exhibits good bench stability and is compatible with standard purification protocols, making it suitable for scale-up applications in API development.
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GHS Pictogram :
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GHS No : GHS05
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Signal Word : Danger
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UN#: 2735
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H302-H318
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: