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CS-W001157 4
Total: USD 88.00

3-Chloro-5-fluoropicolinic acid

  • CAS No. 128073-01-8

  • Cat. No. CS-0079379
  • Purity≥97%
  • MDL No.MFCD13185822

*For research and further manufacturing use only, not for direct human use.

3-Chloro-5-fluoropicolinic acid|CS-0079379

Structure of 128073-01-8

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General Information

  • CAS No. 128073-01-8
  • Cat. No. CS-0079379
  • Purity ≥97%
  • MDL No. MFCD13185822
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃ClFNO₂
  • Molecular Weight 175.54
  • Synonym(s) 3-Chloro-5-fluoropyridine-2-carboxylic acid
  • SMILES O=C(C1=NC=C(F)C=C1Cl)O

Description

3-Chloro-5-fluoropicolinic acid features a strategically positioned chloro and fluoro substituent on the picolinic acid scaffold, enhancing electron-withdrawal and metabolic stability. This combination imparts favorable solubility and reactivity profiles for use in pharmaceutical intermediates, enabling efficient coupling reactions under mild conditions.

Application

3-Chloro-5-fluoropicolinic acid serves as a valuable building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles through standard coupling and cyclization protocols. Its orthogonal halogenation pattern facilitates selective functionalization, while the carboxylic acid group supports direct derivatization or incorporation into peptide-like scaffolds. Bench-stable and readily purified, it functions reliably in multi-step syntheses requiring precise regiocontrol and functional group compatibility.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.5723
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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