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CS-W001157 4
Total: USD 88.00

5-(Difluoromethyl)-1H-pyrazol-3-amine

  • CAS No. 1284220-49-0

  • Cat. No. CS-0050756
  • Molecule weight133.10
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-(Difluoromethyl)-1H-pyrazol-3-amine|CS-0050756

Structure of 1284220-49-0

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General Information

  • CAS No. 1284220-49-0
  • Cat. No. CS-0050756
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₅F₂N₃
  • Molecular Weight 133.10
  • Synonym(s) 5-AMino-3-(difluoroMethyl)-1H-pyrazole
  • SMILES NC1=NNC(=C1)C(F)F

Description

5-(Difluoromethyl)-1H-pyrazol-3-amine features a difluoromethyl group appended to a pyrazole scaffold, imparting enhanced metabolic stability and modulated lipophilicity. This electron-deficient heterocycle integrates readily into medicinal chemistry campaigns targeting kinase inhibitors and CNS-active compounds.

Application

5-(Difluoromethyl)-1H-pyrazol-3-amine serves as a versatile building block in medicinal chemistry, enabling the introduction of a polar, metabolically stable difluoromethyl group adjacent to a hydrogen-bonding pyrazole amine. Its functional group tolerance facilitates coupling reactions and downstream derivatization, while the scaffold exhibits favorable bench stability and ease of purification—ideal for rapid SAR exploration in drug discovery programs.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   54.7
  • LogP   0.9295
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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