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Structure of 1286734-85-7
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6-Bromo-5-fluoro-1H-indazole is a halogenated indazole scaffold featuring complementary bromine and fluorine substituents at the 6- and 5-positions, respectively. This electron-deficient heterocycle serves as a key building block in medicinal chemistry, enabling direct coupling reactions via palladium-catalyzed cross-coupling. The strategic placement of halogens supports efficient diversification in target-oriented synthesis.
6-Bromo-5-fluoro-1H-indazole serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its complementary halogen reactivity. The bromo group facilitates Suzuki, Stille, and Negishi couplings, while the fluorine enhances metabolic stability and modulates electronic properties. Its bench-stable crystalline form simplifies handling and purification, making it well-suited for iterative synthesis of complex heterocyclic scaffolds and API intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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