Boc-D-Pyroglutaminol

Name: Boc-D-Pyroglutaminol
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 128811-37-0
Cat. No. CS-0154804
Purity≥95%
MDL No.MFCD12911763

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Structure of 128811-37-0

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Description

Boc-D-Pyroglutaminol features a protected D-pyroglutamine scaffold with a hydroxyl group, enabling direct incorporation into peptide sequences. The Boc group ensures stability during synthesis, while the pendant alcohol facilitates conjugation or derivatization. This building block supports efficient access to cyclic peptides and bioactive analogs under standard conditions.

Application

Boc-D-Pyroglutaminol serves as a stable, bench-ready building block for the synthesis of D-pyrrolidin-2-one derivatives and cyclic peptide intermediates. Its N-Boc protection ensures compatibility with diverse coupling conditions, while the hydroxyl group enables selective derivatization or further functionalization. This chiral scaffold facilitates efficient access to bioactive heterocycles and is particularly valuable in the construction of constrained peptidomimetics and kinase inhibitor scaffolds.

General Information

CAS No. 128811-37-0
Cat. No. CS-0154804
Purity ≥95%
MDL No. MFCD12911763
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₇NO₄
Molecular Weight None
Synonym(s) tert-Butyl (2R)-2-(hydroxymethyl)-5-oxopyrrolidine-1-carboxylate USP/EP/BP
SMILES CC(C)(C)OC(=O)N1[C@H](CCC1=O)CO

Computational Chemistry Data

TPSA 66.84
LogP 0.9048
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Alcohol

Building Blocks Skeleton Aliphatic heterocycle compounds Pyrrolidine compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

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Boc-D-Pyroglutaminol

CAS No. 128811-37-0

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