2,6-Dichloro-4-methylpyridin-3-amine

Name: 2,6-Dichloro-4-methylpyridin-3-amine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 129432-25-3
Cat. No. CS-0061274
Purity≥96%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2,6-Dichloro-4-methylpyridin-3-amine|CS-0061274

Structure of 129432-25-3

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Description

2,6-Dichloro-4-methylpyridin-3-amine features a pyridine core bearing two chlorine substituents at the 2 and 6 positions and a methyl group at the 4 position, creating a sterically hindered, electron-deficient heterocyclic scaffold. This configuration enables efficient coupling in cross-coupling reactions and supports incorporation into bioactive molecules requiring precise electronic tuning.

Application

2,6-Dichloro-4-methylpyridin-3-amine serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyridine-based scaffolds. Its electron-deficient pyridine core facilitates nucleophilic substitution reactions, while the methyl and amine groups provide orthogonal handles for further functionalization. The compound exhibits good bench stability and compatibility with standard coupling protocols, making it well-suited for modular synthesis of kinase inhibitors and other bioactive heterocycles.

General Information

CAS No. 129432-25-3
Cat. No. CS-0061274
Purity ≥96%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₆Cl₂N₂
Molecular Weight 177.03
Synonym(s) 2,6-Dichloro-4-methyl-3-aminopyridine
SMILES CC1=CC(=NC(=C1N)Cl)Cl

Computational Chemistry Data

TPSA 38.91
LogP 2.27902
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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2,6-Dichloro-4-methylpyridin-3-amine

CAS No. 129432-25-3

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