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Structure of 129623-61-6
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4-(4-Fluorophenoxy)benzoic acid features a rigid, electron-deficient aromatic core that enhances its utility in pharmaceutical synthesis. The para-fluorophenoxy linkage provides favorable lipophilicity and metabolic stability, while the carboxylic acid group enables direct coupling or derivatization under standard conditions. This structure supports efficient integration into bioactive scaffolds requiring precise spatial orientation and electronic tuning.
4-(4-Fluorophenoxy)benzoic acid serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles and pharmaceutical scaffolds. Its ortho-linked aryl ether and carboxylic acid functionalities offer orthogonal reactivity for derivatization via esterification, amide coupling, or Suzuki-Miyaura cross-coupling. The fluorinated aryl moiety enhances metabolic stability and modulates electronic properties, while the compound exhibits excellent bench stability and ease of purification—ideal for iterative synthesis in API development workflows.
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GHS Pictogram :
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GHS No : GHS07,GHS09
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Signal Word : Warning
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UN#: 3077
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Class : 9
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Packing Group : Ⅲ
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Hazard Statements : H302-H319-H410
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Precautionary Statements : P264-P270-P273-P280-P330-P391-P501
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Lot numbers can be found on the outside label of a product: