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CS-W001157 4
Total: USD 88.00

4-(4-Fluorophenoxy)benzoic acid

  • CAS No. 129623-61-6

  • Cat. No. CS-0045357
  • Purity≥98%
  • MDL No.MFCD01631892
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4-(4-Fluorophenoxy)benzoic acid|CS-0045357

Structure of 129623-61-6

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Description

4-(4-Fluorophenoxy)benzoic acid features a rigid, electron-deficient aromatic core that enhances its utility in pharmaceutical synthesis. The para-fluorophenoxy linkage provides favorable lipophilicity and metabolic stability, while the carboxylic acid group enables direct coupling or derivatization under standard conditions. This structure supports efficient integration into bioactive scaffolds requiring precise spatial orientation and electronic tuning.

Application

4-(4-Fluorophenoxy)benzoic acid serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles and pharmaceutical scaffolds. Its ortho-linked aryl ether and carboxylic acid functionalities offer orthogonal reactivity for derivatization via esterification, amide coupling, or Suzuki-Miyaura cross-coupling. The fluorinated aryl moiety enhances metabolic stability and modulates electronic properties, while the compound exhibits excellent bench stability and ease of purification—ideal for iterative synthesis in API development workflows.

General Information

  • CAS No. 129623-61-6
  • Cat. No. CS-0045357
  • Purity ≥98%
  • MDL No. MFCD01631892
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₉FO₃
  • Molecular Weight 232.21
  • Synonym(s) None
  • SMILES O=C(O)C1=CC=C(OC2=CC=C(F)C=C2)C=C1

Computational Chemistry Data

  • TPSA   46.53
  • LogP   3.3162
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   3

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07,GHS09
Signal Word : Warning
UN#: 3077
Class : 9
Packing Group :
Hazard Statements : H302-H319-H410
Precautionary Statements : P264-P270-P273-P280-P330-P391-P501

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