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Structure of 129822-47-5
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Tert-butyl 5-fluoro-1H-indole-1-carboxylate features a fluoro-substituted indole core with a tert-butoxycarbonyl group at the nitrogen, providing stability and ease of handling. This bench-stable derivative enables straightforward deprotection and functionalization in synthetic sequences. The electron-deficient nature of the 5-fluoro substitution enhances reactivity in cross-coupling and electrophilic aromatic substitution processes.
Tert-butyl 5-fluoro-1H-indole-1-carboxylate serves as a versatile building block for the synthesis of fluorinated indole derivatives. The tert-butyl carbamate group provides stability and facilitates selective deprotection under mild acidic conditions, while the 5-fluoro substituent enables site-specific functionalization via palladium-catalyzed cross-coupling or electrophilic substitution. Its robustness and compatibility with standard synthetic protocols make it a practical choice for medicinal chemistry campaigns targeting bioactive indole scaffolds.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: