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Structure of 130046-91-2
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5-Fluoro-2-hydroxy-3-nitrobenzoic acid features a fluorine atom at the 5-position, a hydroxyl group ortho to the carboxylic acid, and a nitro group at the 3-position, creating a highly electron-deficient aromatic core. This combination enables direct functionalization in cross-coupling reactions and facilitates conjugation in bioconjugate chemistry. The molecule exhibits enhanced solubility in polar solvents and stability under standard bench conditions.
5-Fluoro-2-hydroxy-3-nitrobenzoic acid serves as a versatile building block for heterocyclic synthesis and medicinal chemistry campaigns. Its ortho-hydroxyl and meta-nitro groups enable directed metalation and regioselective functionalization, while the carboxylic acid facilitates derivatization via amide or ester formation. The fluorine substituent enhances metabolic stability and modulates electronic properties, offering favorable handling characteristics and compatibility with standard purification protocols.
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GHS Pictogram :
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GHS No : GHS05,GHS07,GHS09
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Signal Word : Danger
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UN#: 3077
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Class : 9
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Packing Group : Ⅲ
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Hazard Statements : H302-H315-H317-H318-H410
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Precautionary Statements : P261-P264-P270-P272-P273-P280-P302+P352-P330-P362+P364-P391-P501
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Lot numbers can be found on the outside label of a product: