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CS-W001157 4
Total: USD 88.00

1-(Methoxymethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

  • CAS No. 1301198-65-1

  • Cat. No. CS-0175704
  • Purity≥95%
  • MDL No.None
  • HazMat Fee +

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    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

1-(Methoxymethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole|CS-0175704

Structure of 1301198-65-1

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Description

1-(Methoxymethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole features a boronate ester group enabling reliable Suzuki-Miyaura cross-coupling reactions. The methoxymethyl substituent enhances solubility and stability under standard conditions. This compound serves as a robust building block for constructing complex heterocyclic architectures in medicinal chemistry and materials science.

Application

1-(Methoxymethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole serves as a versatile boronate building block for Suzuki-Miyaura cross-coupling reactions. The pyrazole core provides metabolic stability and hydrogen-bonding capacity, while the methoxymethyl group offers orthogonal protection and mild deprotection conditions. The pinacol boronate moiety enables high functional group tolerance, excellent bench stability, and compatibility with diverse reaction conditions, facilitating efficient assembly of complex heterocyclic scaffolds in medicinal chemistry and materials science applications.

General Information

  • CAS No. 1301198-65-1
  • Cat. No. CS-0175704
  • Purity ≥95%
  • MDL No. None
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₉BN₂O₃
  • Molecular Weight 238.09
  • Synonym(s) (1-(METHOXYMETHYL)-1H-PYRAZOL-4-YL)BORONIC ACID PINACOL ESTER
  • SMILES CC1(C(C)(OB(O1)C2=CN(N=C2)COC)C)C

Computational Chemistry Data

  • TPSA   45.51
  • LogP   0.7862
  • H_Acceptors   5
  • H_Donors   0
  • Rotatable_Bonds   3

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H320-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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