6-Bromo-5-chloropyridin-3-amine

Name: 6-Bromo-5-chloropyridin-3-amine
Brand: ChemScene
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CAS No. 130284-52-5
Cat. No. CS-0040861
Purity≥96%
MDL No.MFCD09835243

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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6-Bromo-5-chloropyridin-3-amine|CS-0040861

Structure of 130284-52-5

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Description

6-Bromo-5-chloropyridin-3-amine features a pyridine core functionalized with bromo and chloro substituents at the 6- and 5-positions, respectively, and an amine group at C3. This electron-deficient heterocycle enables direct coupling in cross-coupling reactions, serving as a key building block for pharmaceutical intermediates and agrochemical scaffolds. The molecule exhibits good stability under standard handling conditions.

Application

6-Bromo-5-chloropyridin-3-amine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen reactivity. The bromo group facilitates Suzuki-Miyaura and Buchwald-Hartwig couplings, while the chloro substituent offers stability under standard reaction conditions. Its primary amine functionality supports direct derivatization or incorporation into heterocyclic scaffolds. The compound exhibits good bench stability and is readily purified by silica gel chromatography, making it suitable for iterative synthesis workflows in API development.

General Information

CAS No. 130284-52-5
Cat. No. CS-0040861
Purity ≥96%
MDL No. MFCD09835243
Storage RT, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₄BrClN₂
Molecular Weight 207.46
Synonym(s) 6-Bromo-5-chloro-3-pyridinamine
SMILES NC1=CC(Cl)=C(Br)N=C1

Computational Chemistry Data

TPSA 38.91
LogP 2.0797
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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6-Bromo-5-chloropyridin-3-amine

CAS No. 130284-52-5

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