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Structure of 1303972-81-7
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This difluorinated piperidine derivative features a tert-butyl carbamate-protected amine and a carboxylic acid group, enabling direct incorporation into peptide backbones. The fluorinated ring imparts enhanced metabolic stability and modulates electronic properties for optimized binding affinity in bioactive molecule design.
1-(tert-Butoxycarbonyl)-3,3-difluoropiperidine-4-carboxylic acid serves as a valuable building block in medicinal chemistry, enabling the incorporation of a sterically constrained, electron-deficient piperidine motif with enhanced metabolic stability. The difluoro substitution at C3 enhances lipophilicity and modulates basicity, while the Boc-protected carboxylic acid facilitates straightforward coupling reactions and orthogonal deprotection. Its bench-stable nature and compatibility with standard peptide synthesis protocols make it ideal for constructing bioactive heterocyclic scaffolds in drug discovery campaigns.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: