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Structure of 13040-89-6
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5-Chloro-6-methylpyrimidin-4-amine features a pyrimidine core with complementary electron-withdrawing and donating substituents, enabling efficient coupling in cross-coupling reactions. This bench-stable heterocycle integrates readily into pharmaceutical scaffolds, offering enhanced metabolic stability and targeted bioactivity through its balanced electronic profile.
5-Chloro-6-methylpyrimidin-4-amine serves as a versatile building block in medicinal chemistry, enabling efficient access to pyrimidine-based scaffolds through palladium-catalyzed cross-coupling and nucleophilic substitution reactions. Its orthogonal reactivity profile—leveraging the chloro group for C–H functionalization and the amine for derivatization—facilitates rapid diversification of heterocyclic cores. The compound exhibits excellent bench stability, ease of purification, and compatibility with common protecting group strategies, making it well-suited for high-throughput synthesis and API development workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: