(3-Aminooxetan-3-yl)methanol

Name: (3-Aminooxetan-3-yl)methanol
Brand: ChemScene
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CAS No. 1305208-37-0
Cat. No. CS-0040896
Purity≥97%
MDL No.MFCD20926150

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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Description

(3-Aminooxetan-3-yl)methanol is a bench-stable, moisture-tolerant heterocyclic building block featuring a strained oxetane ring fused to an amino-methanol side chain. This combination delivers high reactivity in conjugate additions and nucleophilic transformations, enabling efficient incorporation into bioactive molecules. The primary amine and hydroxyl groups offer dual functionalization points for downstream derivatization, supporting rapid access to complex scaffolds in medicinal chemistry and peptide conjugation workflows.

Application

(3-Aminooxetan-3-yl)methanol serves as a versatile building block in medicinal chemistry, enabling the introduction of a polar, strained oxetane ring with a primary amine and hydroxyl group at the same carbon. Its bench-stable nature and compatibility with standard coupling reactions facilitate efficient incorporation into bioactive molecules. The molecule functions as a key intermediate in the synthesis of heterocyclic scaffolds and API candidates, offering enhanced solubility and metabolic stability through strategic oxetane integration.

General Information

CAS No. 1305208-37-0
Cat. No. CS-0040896
Purity ≥97%
MDL No. MFCD20926150
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₄H₉NO₂
Molecular Weight 103.12
Synonym(s) 3-amino-3-hydroxymethyloxetane
SMILES OCC1(N)COC1

Computational Chemistry Data

TPSA 55.48
LogP -1.2936
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Alcohol

Building Blocks Skeleton Aliphatic heterocycle compounds Oxetane compounds

Key Words

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(3-Aminooxetan-3-yl)methanol

CAS No. 1305208-37-0

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