7-Bromo-1,5-naphthyridin-2-amine

Name: 7-Bromo-1,5-naphthyridin-2-amine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 1309774-04-6
Cat. No. CS-0475526
Purity≥98%
MDL No.MFCD29089336

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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7-Bromo-1,5-naphthyridin-2-amine|CS-0475526

Structure of 1309774-04-6

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Description

7-Bromo-1,5-naphthyridin-2-amine features a brominated naphthyridine core with a strategically positioned amine group, enabling direct coupling in cross-coupling reactions. This electron-deficient heterocycle offers enhanced reactivity in palladium-catalyzed transformations and serves as a key scaffold for constructing complex nitrogen-containing architectures in medicinal chemistry and materials science.

Application

7-Bromo-1,5-naphthyridin-2-amine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its well-defined halogen reactivity. The amino group provides a handle for derivatization, while the naphthyridine core offers enhanced metabolic stability and favorable binding properties in target-directed synthesis. Bench-stable and readily purified, it functions effectively in standard synthetic workflows for constructing heterocyclic scaffolds relevant to kinase inhibitors and other bioactive molecules.

General Information

CAS No. 1309774-04-6
Cat. No. CS-0475526
Purity ≥98%
MDL No. MFCD29089336
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₆BrN₃
Molecular Weight 224.06
Synonym(s) None
SMILES NC1N=C2C(=CC=1)N=CC(Br)=C2

Computational Chemistry Data

TPSA 51.8
LogP 1.9745
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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7-Bromo-1,5-naphthyridin-2-amine

CAS No. 1309774-04-6

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