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Structure of 13101-83-2
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6-Fluoronaphthalen-2-ol features a fluorine atom at the 6-position of the naphthalene core, flanked by a phenolic hydroxyl group at the 2-position. This combination imparts enhanced electron-withdrawing character and improved solubility in polar solvents. The molecule exhibits bench-stable behavior under standard conditions and serves as a key building block for bioactive heterocycles and functional materials.
6-Fluoronaphthalen-2-ol serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the 2-position via nucleophilic substitution due to activation by the adjacent hydroxyl group. Its bench-stable nature and compatibility with common coupling reactions facilitate efficient synthesis of naphthalene-based scaffolds. The fluorine substituent enhances metabolic stability and modulates electronic properties, making it valuable for optimizing bioactive compounds.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: