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CS-W001157 4
Total: USD 88.00

5-(Chloromethyl)thiazole hydrochloride

  • CAS No. 131052-44-3

  • Cat. No. CS-W006753
  • Molecule weight170.06
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-(Chloromethyl)thiazole hydrochloride|CS-W006753

Structure of 131052-44-3

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General Information

  • CAS No. 131052-44-3
  • Cat. No. CS-W006753
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₅Cl₂NS
  • Molecular Weight 170.06
  • Synonym(s) thiazole hydrochloride
  • SMILES ClCC1=CN=CS1.Cl

Description

5-(Chloromethyl)thiazole hydrochloride features a reactive chloromethyl group attached to the thiazole ring, enabling efficient functionalization in synthetic workflows. This bench-stable, moisture-tolerant reagent integrates readily into heterocyclic architectures and serves as a key intermediate for pharmaceutical and agrochemical derivatization.

Application

5-(Chloromethyl)thiazole hydrochloride serves as a versatile building block for constructing thiazole-based scaffolds in medicinal chemistry and materials science. The chloromethyl group enables efficient nucleophilic substitution, facilitating C–C and C–heteroatom bond formation under mild conditions. Its stability under standard bench handling and compatibility with diverse functional groups make it ideal for iterative synthesis workflows. Functions as a key intermediate in the preparation of bioactive heterocycles and functionalized polymers.

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅱ
Hazard Statements : H302-H314
Precautionary Statements : P260-P264-P270-P280-P301+P330+P331-P304+P340-P363-P405-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.3037
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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