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CS-W001157 4
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5-Chloro-2-pyrazinecarboxylic acid

  • CAS No. 36070-80-1

  • Cat. No. CS-B0945
  • Molecule weightNone
  • Purity≥95%
  • MDL No.MFCD09033269

*For research and further manufacturing use only, not for direct human use.

5-Chloro-2-pyrazinecarboxylic acid|CS-B0945

Structure of 36070-80-1

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General Information

  • CAS No. 36070-80-1
  • Cat. No. CS-B0945
  • Purity ≥95%
  • MDL No. MFCD09033269
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃ClN₂O₂
  • Molecular Weight None
  • Synonym(s) 5-Chloropyrazine-2-carboxylic acid
  • SMILES O=C(C1=NC=C(Cl)N=C1)O

Description

5-Chloro-2-pyrazinecarboxylic acid features a chlorinated pyrazine core with a carboxylic acid group at the 2-position, enabling direct conjugation in synthetic transformations. This electron-deficient heterocycle integrates readily into pharmaceutical intermediates and functional materials, offering enhanced reactivity under standard conditions.

Application

5-Chloro-2-pyrazinecarboxylic acid serves as a versatile building block for heterocyclic synthesis, enabling direct functionalization at the pyrazine core. Its carboxylic acid group facilitates amide formation, esterification, and coupling reactions under standard conditions, while the chloro substituent supports nucleophilic aromatic substitution and transition-metal-catalyzed cross-couplings. The molecule exhibits good bench stability and is readily purified by recrystallization, making it suitable for medicinal chemistry campaigns and API intermediate development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   63.08
  • LogP   0.8282
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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