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CS-W001157 4
Total: USD 88.00

(4-Iodophenyl)hydrazine

  • CAS No. 13116-27-3

  • Cat. No. CS-0186076
  • Molecule weight234.04
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(4-Iodophenyl)hydrazine|CS-0186076

Structure of 13116-27-3

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General Information

  • CAS No. 13116-27-3
  • Cat. No. CS-0186076
  • Purity ≥95%
  • MDL No. None
  • Storage -20°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇IN₂
  • Molecular Weight 234.04
  • Synonym(s) 4-Iodophenylhydrazine
  • SMILES C1=C(C=CC(=C1)NN)I

Description

Cortisol, steroid hormone is released in response to stress and a low level of blood glucocorticoids. Its primary functions is to increase blood sugar through gluconeogenesis, suppress the immune system, and aid in fat, protein and carbohydrate metabolism.

Application

(4-Iodophenyl)hydrazine serves as a versatile building block in the synthesis of biaryl scaffolds and heterocycles, enabling efficient coupling reactions via Pd-catalyzed cross-coupling protocols. Its iodine functionality provides high reactivity in Suzuki, Stille, and Negishi couplings, while the hydrazine group offers orthogonal handles for further functionalization. Bench-stable and readily purified by recrystallization, it functions reliably in multi-step synthetic sequences targeting pharmaceutical intermediates and agrochemicals.

Synthesis

  • Route1

    References

    • Klotz, Eric J. F.; Claridge, Tim D. W.; Anderson, Harry L. Journal of the American Chemical Society, 2006 , vol. 128, # 48 p. 15374 - 15375
  • Route2

    References

    • Zynaxis, Inc. Patent: US5667764 A1, 1997 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H317-H319-H335
Precautionary Statements : P261-P264-P270-P271-P272-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   38.05
  • LogP   1.5768
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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