Fmoc-norArg(Pbf)-OH

Name: Fmoc-norArg(Pbf)-OH
Brand: ChemScene
Availability: InStock
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CAS No. 1313054-32-8
Cat. No. CS-0166823
Purity≥95%
MDL No.MFCD15142017

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Description

Fmoc-norArg(Pbf)-OH is a protected arginine derivative featuring a Pbf-protected guanidino group and an Fmoc-labile α-amino block. This configuration enables efficient incorporation into peptide chains under standard coupling conditions, offering enhanced solubility and reduced side-reaction risks during solid-phase synthesis.

Application

Fmoc-norArg(Pbf)-OH serves as a key building block in solid-phase peptide synthesis, enabling efficient incorporation of norarginine residues with high fidelity. The Pbf (para-bromophenyl) protecting group ensures excellent orthogonality and stability during standard coupling conditions, while the Fmoc group allows for selective deprotection under mild basic conditions. This derivative exhibits robust bench stability, facilitates clean purification, and supports diverse functionalization in peptide sequences requiring basic side-chain functionality.

General Information

CAS No. 1313054-32-8
Cat. No. CS-0166823
Purity ≥95%
MDL No. MFCD15142017
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₃₃H₃₈N₄O₇S
Molecular Weight 634.74
Synonym(s) (S,E)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(N'-((2,2,4,6,(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-(3-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)guanidino)butanoic acid
SMILES O=S(NC(NCC[C@@H](C(O)=O)NC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O)=N)(C4=C(C)C(C)=C(OC(C)(C5)C)C5=C4C)=O

Computational Chemistry Data

TPSA 155.42
LogP 4.51856
H_Acceptors 7
H_Donors 4
Rotatable_Bonds 11

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Life Science Amino Acids and their Derivatives Arginine and derivatives

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

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Fmoc-norArg(Pbf)-OH

CAS No. 1313054-32-8

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