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Structure of 132554-73-5
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2-Fluoro-1-iodo-4-(trifluoromethyl)benzene features a trifluoromethyl group and iodine at para positions relative to a fluorine substituent, creating a highly electron-deficient aromatic core. This configuration enables efficient cross-coupling reactions under palladium catalysis, delivering complex fluorinated arenes with high regioselectivity. The molecule exhibits enhanced stability and solubility in common organic solvents, facilitating use in diverse synthetic transformations.
2-Fluoro-1-iodo-4-(trifluoromethyl)benzene serves as a versatile aryl building block for palladium-catalyzed cross-coupling reactions. The ortho-iodo and fluoro substituents enable sequential functionalization, while the trifluoromethyl group imparts enhanced metabolic stability and lipophilicity. This compound exhibits excellent bench stability and facilitates efficient coupling with boronic acids, amines, and thiols under standard conditions, making it a reliable scaffold for medicinal chemistry and materials synthesis.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: