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Structure of 132800-13-6
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1-Cyclobutylpiperazine is a sterically constrained piperazine derivative featuring a cyclobutyl group that imparts enhanced lipophilicity and conformational rigidity. This structural profile supports improved membrane permeability and metabolic stability, making it a valuable scaffold in medicinal chemistry for CNS-targeted compounds and bioactive molecule design.
1-Cyclobutylpiperazine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard amine functionalization. Its cyclobutyl substitution imparts enhanced metabolic stability and favorable lipophilicity profiles compared to simpler alkylated piperazines. The molecule exhibits robust bench stability, facilitates straightforward purification, and tolerates a broad range of reaction conditions, making it well-suited for iterative synthesis workflows in API development.
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GHS Pictogram :
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GHS No : GHS06
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Signal Word : Danger
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UN#: 2811
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H301-H315-H319-H335
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Precautionary Statements : P260-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405
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Lot numbers can be found on the outside label of a product: