1-Boc-(S)-2-piperidinemethanol

Name: 1-Boc-(S)-2-piperidinemethanol
Brand: ChemScene
Availability: InStock
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CAS No. 134441-93-3
Cat. No. CS-0028260
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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1-Boc-(S)-2-piperidinemethanol|CS-0028260

Structure of 134441-93-3

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General Information

CAS No. 134441-93-3
Cat. No. CS-0028260
Purity ≥97%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₁H₂₁NO₃
Molecular Weight 215.29
Synonym(s) (S)-tert-Butyl 2-(hydroxymethyl)piperidine-1-carboxylate; 1,1-Dimethylethyl (2S)-2-(hydroxymethyl)piperidine-1-carboxylate; tert-butyl (2S)-2-(hydroxymethyl)piperidine-1-carboxylate
SMILES O=C(N1[C@H](CO)CCCC1)OC(C)(C)C

Description

1-Boc-(S)-2-piperidinemethanol features a chiral piperidine core with a protected hydroxymethyl group, enabling selective functionalization in asymmetric synthesis. This bench-stable derivative integrates readily into complex molecular architectures, offering reliable access to bioactive piperidine scaffolds under standard conditions.

Application

1-Boc-(S)-2-piperidinemethanol serves as a versatile chiral building block for the synthesis of piperidine-based pharmaceutical intermediates. The Boc-protected amine enables straightforward functionalization and orthogonal deprotection, while the pendant hydroxyl group supports derivatization via esterification or ether formation. Its bench-stable nature and compatibility with standard coupling protocols facilitate efficient access to complex heterocyclic scaffolds in medicinal chemistry and process development workflows.

Synthesis

Route1
- In-stock
  
  24424-99-5
- In-stock
  
  41373-39-1
- ~90%
- In-stock
  
  134441-93-3
References
- Bhat, Chinmay; Tilve, Santosh G. Tetrahedron, 2013 , vol. 69, # 30 p. 6129 - 6143
Route2
- In-stock
  
  26250-84-0
- ~97%
- In-stock
  
  134441-93-3
References
- Wilkinson; Stehle; Beak Organic letters, 2000 , vol. 2, # 2 p. 155 - 158
Route3
- 1201635-96-2
- ~90%
- In-stock
  
  134441-93-3
References
- Shaikh, Tanveer Mahamadali; Sudalai, Arumugam Tetrahedron Asymmetry, 2009 , vol. 20, # 19 p. 2287 - 2292

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 49.77
LogP 1.7683
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Alcohol

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Key Words

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1-Boc-(S)-2-piperidinemethanol

CAS No. 134441-93-3

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