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Structure of 1346808-41-0
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5-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoxazole is a bench-stable boronate ester featuring a methyl-substituted isoxazole core. This compound integrates seamlessly into Suzuki-Miyaura cross-coupling reactions, enabling efficient C–C bond formation under mild conditions. The sterically protected boronate moiety enhances stability and reactivity in aqueous or protic solvents.
5-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoxazole serves as a stable, bench-ready boronate building block for Suzuki-Miyaura cross-coupling reactions. The isoxazole core provides a bioisostere-relevant heterocyclic scaffold with moderate electron-withdrawing character, while the pinacol boronate group enables reliable C–C bond formation under standard catalytic conditions. Its functional group tolerance and ease of purification make it well-suited for iterative synthesis in medicinal chemistry and materials science applications.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: