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Structure of 4857-42-5
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3-Methylisoxazole-5-carboxylic acid features a fused heterocyclic core with complementary electron-rich and electron-deficient regions, enabling versatile coupling reactions. The carboxylic acid group provides a robust handle for amide formation, while the methyl substituent enhances solubility and metabolic stability. This scaffold integrates readily into bioactive molecules, offering favorable pharmacokinetic profiles in medicinal chemistry applications.
3-Methylisoxazole-5-carboxylic acid serves as a versatile heterocyclic building block for medicinal chemistry and materials science. Its orthogonal reactivity enables direct functionalization at the carboxylic acid group, facilitating amide coupling, esterification, or activation for nucleophilic substitution. The methyl and isoxazole functionalities provide structural rigidity and favorable pharmacophore properties, enhancing metabolic stability in bioactive molecule design. Bench-stable and readily purified by recrystallization, it integrates seamlessly into standard synthetic workflows for API intermediates and advanced catalysts.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: