tert-Butyl (2-chloro-3-fluoropyridin-4-yl)carbamate

Name: tert-Butyl (2-chloro-3-fluoropyridin-4-yl)carbamate
Brand: ChemScene
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CAS No. 1354223-71-4
Cat. No. CS-0146135
Purity≥98%
MDL No.MFCD23162426

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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tert-Butyl (2-chloro-3-fluoropyridin-4-yl)carbamate|CS-0146135

Structure of 1354223-71-4

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Description

tert-Butyl (2-chloro-3-fluoropyridin-4-yl)carbamate delivers a strategically functionalized pyridine scaffold bearing orthogonal halogen and fluorine handles. This bench-stable, moisture-tolerant carbamate integrates readily into cross-coupling and late-stage diversification workflows. The protected amine facilitates efficient downstream transformations under standard conditions.

Application

tert-Butyl (2-chloro-3-fluoropyridin-4-yl)carbamate serves as a versatile pyridine-based building block for medicinal chemistry and process development. The ortho-halogenated pyridine core enables palladium-catalyzed cross-coupling reactions, while the tert-butyl carbamate group provides stability and facilitates selective deprotection under mild acidic conditions. Its functional group tolerance supports downstream modifications in multi-step synthesis, making it ideal for constructing complex heterocyclic scaffolds used in pharmaceutical discovery.

General Information

CAS No. 1354223-71-4
Cat. No. CS-0146135
Purity ≥98%
MDL No. MFCD23162426
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₂ClFN₂O₂
Molecular Weight 246.67
Synonym(s) tert-butyl N-(2-chloro-3-fluoropyridin-4-yl)carbamate
SMILES CC(C)(C)OC(NC(C=CN=C1Cl)=C1F)=O

Computational Chemistry Data

TPSA 51.22
LogP 3.2211
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H312-H332
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501

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Other Classifications

Building Blocks Functional Group Amine

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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tert-Butyl (2-chloro-3-fluoropyridin-4-yl)carbamate

CAS No. 1354223-71-4

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