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CS-W001157 4
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Terephthalic Dihydrazide

  • CAS No. 136-64-1

  • Cat. No. CS-0157590
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Terephthalic Dihydrazide|CS-0157590

Structure of 136-64-1

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General Information

  • CAS No. 136-64-1
  • Cat. No. CS-0157590
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₀N₄O₂
  • Molecular Weight 194.19
  • Synonym(s) Terephthalohydrazide
  • SMILES C1=C(C=CC(=C1)C(=O)NN)C(=O)NN

Description

Terephthalic dihydrazide features two hydrazide groups flanking a rigid aromatic core, enabling robust coordination in metal-organic frameworks. This structure supports precise spatial control in supramolecular assembly and enhances stability under standard handling conditions.

Application

Terephthalic dihydrazide serves as a versatile building block in the synthesis of functionalized heterocycles and coordination polymers. Its two hydrazide groups enable reliable condensation reactions with aldehydes and ketones, facilitating the formation of hydrazone-linked frameworks under mild conditions. The aromatic core provides structural rigidity and thermal stability, while the terminal hydrazide functionalities offer excellent tolerance to diverse reaction environments, simplifying purification and enabling scalable applications in materials chemistry and medicinal scaffolds.

Synthesis

  • Route1

    References

    • Zhang, Xiao-bing; Tang, Ben-chen; Zhang, Peng; Li, Min; Tian, Wen-jing Journal of Molecular Structure, 2007 , vol. 846, # 1-3 p. 55 - 64
  • Route2

    References

    • Lyakhov; Lyakhova; Panchenko; Litvinova; Andronati Pharmaceutical Chemistry Journal, 2001 , vol. 35, # 12 p. 653 - 656
  • Route3
    • null|null
      100-20-9
    • ~93%
    • In-stock
      Terephthalic Dihydrazide|CS-0157590
      136-64-1

    References

    • Mobinikhaledi, Akbar; Foroughifar, Naser; Rafiee, Abdolhossein Heterocyclic Communications, 2013 , vol. 19, # 4 p. 265 - 269

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   110.24
  • LogP   -1.1064
  • H_Acceptors   4
  • H_Donors   4
  • Rotatable_Bonds   2

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