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tert-Butyl 7-hydroxy-2-azaspiro[3.5]nonane-2-carboxylate

  • CAS No. 1363383-18-9

  • Cat. No. CS-0042478
  • Purity≥95%
  • MDL No.MFCD20926146
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

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    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 7-hydroxy-2-azaspiro[3.5]nonane-2-carboxylate|CS-0042478

Structure of 1363383-18-9

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Description

tert-Butyl 7-hydroxy-2-azaspiro[3.5]nonane-2-carboxylate features a rigid spirocyclic scaffold with a pendant hydroxyl group and a bench-stable tert-butyl carbamate. This configuration enables direct functionalization at the C7 position while maintaining structural integrity under standard reaction conditions. The molecule serves as a key intermediate in the synthesis of complex nitrogen-containing polycycles, particularly in medicinal chemistry campaigns targeting bioactive alkaloid analogs.

Application

tert-Butyl 7-hydroxy-2-azaspiro[3.5]nonane-2-carboxylate serves as a versatile spirocyclic scaffold for medicinal chemistry applications, enabling efficient access to complex nitrogen-containing heterocycles. The pendant hydroxyl group offers direct handle for derivatization via esterification, etherification, or oxidation, while the tert-butyl carbamate protects the amine under standard synthetic conditions. Its stability, ease of purification, and compatibility with diverse coupling reactions make it a practical building block for target-oriented synthesis.

General Information

  • CAS No. 1363383-18-9
  • Cat. No. CS-0042478
  • Purity ≥95%
  • MDL No. MFCD20926146
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₂₃NO₃
  • Molecular Weight 241.33
  • Synonym(s) 7-Hydroxy-2-azaspiro[3.5]nonane-2-carboxylic acid 1,1-dimethylethyl ester
  • SMILES O=C(N1CC2(CCC(O)CC2)C1)OC(C)(C)C

Computational Chemistry Data

  • TPSA   49.77
  • LogP   2.1584
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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