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5-Chloro-3-(trifluoromethyl)pyrazin-2-amine

  • CAS No. 1364663-32-0

  • Cat. No. CS-0196713
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-Chloro-3-(trifluoromethyl)pyrazin-2-amine|CS-0196713

Structure of 1364663-32-0

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General Information

  • CAS No. 1364663-32-0
  • Cat. No. CS-0196713
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, sealed storage, away from moisture and light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃ClF₃N₃
  • Molecular Weight 197.55
  • Synonym(s) 5-Chloro-3-trifluoromethyl-pyrazin-2-ylamine
  • SMILES NC1=NC=C(Cl)N=C1C(F)(F)F

Description

5-Chloro-3-(trifluoromethyl)pyrazin-2-amine delivers a potent electron-deficient heterocyclic scaffold featuring a chlorine substituent at C5 and a trifluoromethyl group at C3. This combination enhances metabolic stability and modulates electronic properties, enabling efficient coupling in transition-metal-catalyzed transformations. The molecule's bench-stable nature supports straightforward handling in synthetic workflows.

Application

5-Chloro-3-(trifluoromethyl)pyrazin-2-amine serves as a versatile building block in medicinal chemistry, enabling efficient construction of heterocyclic scaffolds via palladium-catalyzed cross-coupling reactions. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the chloro and amino functionalities offer orthogonal reactivity for further functionalization. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for scalable synthesis and API development workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   51.8
  • LogP   1.731
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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