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Structure of 1364663-32-0
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5-Chloro-3-(trifluoromethyl)pyrazin-2-amine delivers a potent electron-deficient heterocyclic scaffold featuring a chlorine substituent at C5 and a trifluoromethyl group at C3. This combination enhances metabolic stability and modulates electronic properties, enabling efficient coupling in transition-metal-catalyzed transformations. The molecule's bench-stable nature supports straightforward handling in synthetic workflows.
5-Chloro-3-(trifluoromethyl)pyrazin-2-amine serves as a versatile building block in medicinal chemistry, enabling efficient construction of heterocyclic scaffolds via palladium-catalyzed cross-coupling reactions. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the chloro and amino functionalities offer orthogonal reactivity for further functionalization. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for scalable synthesis and API development workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: