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CS-W001157 4
Total: USD 88.00

3-Bromo-1-methyl-1H-1,2,4-triazol-5-amine

  • CAS No. 1365957-74-9

  • Cat. No. CS-0435657
  • Purity≥98%
  • MDL No.None
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

3-Bromo-1-methyl-1H-1,2,4-triazol-5-amine|CS-0435657

Structure of 1365957-74-9

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Description

3-Bromo-1-methyl-1H-1,2,4-triazol-5-amine features a brominated triazole core with a methylated nitrogen at the 1-position, enabling direct incorporation into heterocyclic scaffolds. This bench-stable compound serves as a key building block for bioactive molecules in medicinal chemistry, particularly in kinase inhibitor and antifungal agent development.

Application

3-Bromo-1-methyl-1H-1,2,4-triazol-5-amine serves as a versatile building block in medicinal chemistry, enabling efficient access to triazolyl-based heterocycles via cross-coupling and nucleophilic substitution reactions. The bromo group facilitates palladium-catalyzed transformations, while the 1-methyl-1H-1,2,4-triazole scaffold offers enhanced metabolic stability and hydrogen-bonding capacity. This compound exhibits good bench stability, simplifies purification, and demonstrates broad functional group tolerance, making it well-suited for iterative synthesis of bioactive molecules and API intermediates.

General Information

  • CAS No. 1365957-74-9
  • Cat. No. CS-0435657
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃H₅BrN₄
  • Molecular Weight 177.00
  • Synonym(s) None
  • SMILES NC1=NC(Br)=NN1C

Computational Chemistry Data

  • TPSA   56.73
  • LogP   0.1598
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3259
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H315-H318-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

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