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*For research and further manufacturing use only, not for direct human use.
Structure of 136834-22-5
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DMT-2′-fluoro-dA(bz) amidite delivers a protected 2′-fluoro-modified adenosine building block with enhanced nuclease resistance and improved duplex stability. The benzoyl group at the N6 position ensures selective incorporation during solid-phase synthesis, while the DMT protecting group enables efficient purification and stepwise chain elongation under standard conditions.
DMT-2'-fluoro-dA(Bz) amidite serves as a key building block for the solid-phase synthesis of oligonucleotides incorporating 2'-fluoro-modified adenosine residues. The DMT group provides orthogonal protection for the 5'-end, enabling efficient deprotection and purification post-synthesis. The 2'-fluoro substitution enhances nuclease resistance and improves binding affinity to complementary RNA targets, while the benzoyl (Bz) group ensures reliable base protection during synthesis. This amidite exhibits excellent coupling efficiency and stability under standard phosphoramidite conditions, making it well-suited for routine use in the construction of therapeutic and research oligonucleotides.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: