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5-Chloro-1,3-dihydro-2H-pyrrolo[2,3-c]pyridin-2-one

  • CAS No. 136888-17-0

  • Cat. No. CS-0044719
  • Molecule weight168.58
  • Purity≥95%
  • MDL No.MFCD11518942

*For research and further manufacturing use only, not for direct human use.

5-Chloro-1,3-dihydro-2H-pyrrolo[2,3-c]pyridin-2-one|CS-0044719

Structure of 136888-17-0

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General Information

  • CAS No. 136888-17-0
  • Cat. No. CS-0044719
  • Purity ≥95%
  • MDL No. MFCD11518942
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅ClN₂O
  • Molecular Weight 168.58
  • Synonym(s) 5-chloro-1H-pyrrolo[2,3-c]pyridin-2(3H)-one
  • SMILES O=C(N1)CC2=C1C=NC(Cl)=C2

Description

5-Chloro-1,3-dihydro-2H-pyrrolo[2,3-c]pyridin-2-one is a heterocyclic scaffold featuring a chlorinated pyrrolopyridinone core, offering enhanced electronic properties and metabolic stability. This electron-deficient framework integrates readily into medicinal chemistry campaigns, serving as a key building block for kinase inhibitors and other bioactive molecules.

Application

5-Chloro-1,3-dihydro-2H-pyrrolo[2,3-c]pyridin-2-one serves as a versatile heterocyclic building block for medicinal chemistry and process development. Its electrophilic chlorine at the 5-position enables palladium-catalyzed cross-coupling reactions, while the lactam functionality offers hydrogen-bonding capability and metabolic stability. The scaffold exhibits excellent bench stability and compatibility with diverse functional groups, facilitating rapid diversification in target-oriented synthesis.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   41.99
  • LogP   1.2296
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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