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CS-W001157 4
Total: USD 88.00

1,3-Difluoro-2-iodobenzene

  • CAS No. 13697-89-7

  • Cat. No. CS-0059149
  • Purity≥97%
  • MDL No.None
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

1,3-Difluoro-2-iodobenzene|CS-0059149

Structure of 13697-89-7

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Description

1,3-Difluoro-2-iodobenzene is a fluorinated aryl iodide featuring complementary halogen substitution patterns that enable selective cross-coupling reactions. The ortho-iodo group facilitates palladium-catalyzed transformations, while the difluoro substitution enhances electronic tuning and metabolic stability. This molecule serves as a key intermediate in the synthesis of bioactive heterocycles and functionalized aromatic scaffolds.

Application

1,3-Difluoro-2-iodobenzene serves as a versatile aryl building block in transition-metal-catalyzed cross-coupling reactions, enabling efficient access to substituted biaryls and heterocycles. The ortho-iodo group facilitates palladium-catalyzed coupling with high regioselectivity, while the difluoro substitution enhances metabolic stability and modulates electronic properties—making it valuable for medicinal chemistry and materials synthesis. Bench-stable and readily purified, it functions reliably in standard synthetic workflows.

General Information

  • CAS No. 13697-89-7
  • Cat. No. CS-0059149
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃F₂I
  • Molecular Weight 239.99
  • Synonym(s) 2,6-Difluoroiodobenzene
  • SMILES IC1=C(F)C=CC=C1F

Computational Chemistry Data

  • TPSA   0
  • LogP   2.5694
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P302+P352-P304+P340

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