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(S)-6-Fluoro-1,2,3,4-tetrahydronaphthalen-1-amine hydrochloride

  • CAS No. 1373232-27-9

  • Cat. No. CS-0155369
  • Purity≥98%
  • MDL No.MFCD22056324

*For research and further manufacturing use only, not for direct human use.

(S)-6-Fluoro-1,2,3,4-tetrahydronaphthalen-1-amine hydrochloride|CS-0155369

Structure of 1373232-27-9

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General Information

  • CAS No. 1373232-27-9
  • Cat. No. CS-0155369
  • Purity ≥98%
  • MDL No. MFCD22056324
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₃ClFN
  • Molecular Weight 201.67
  • Synonym(s) (1S)-6-fluoro-1,2,3,4-tetrahydronaphthalen-1-amine hydrochloride
  • SMILES C1CC2=CC(=CC=C2[C@H](C1)N)F.Cl

Description

(S)-6-Fluoro-1,2,3,4-tetrahydronaphthalen-1-amine hydrochloride is a chiral amine scaffold featuring a fluorinated tetralin core. This bench-stable derivative bears a primary amine functionality and exhibits enhanced solubility in aqueous and polar organic media. The para-fluorine substitution imparts electron-withdrawing character, modulating reactivity in downstream synthetic transformations. It serves as a key building block in asymmetric synthesis for bioactive molecules and pharmaceutical intermediates.

Application

(S)-6-Fluoro-1,2,3,4-tetrahydronaphthalen-1-amine hydrochloride serves as a chiral building block for medicinal chemistry, enabling the synthesis of fluorinated tetralin scaffolds found in CNS-targeted therapeutics. Its bench-stable hydrochloride salt facilitates handling and purification, while the amine functionality supports diverse transformations including acylation, alkylation, and coupling reactions. The stereochemistry at the tetralin ring ensures predictable stereoselective outcomes in downstream syntheses.

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H318
Precautionary Statements : P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   2.5836
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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