N-(((9H-fluoren-9-yl)methoxy)carbonyl)-N-hexylglycine

Name: N-(((9H-fluoren-9-yl)methoxy)carbonyl)-N-hexylglycine
Brand: ChemScene
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CAS No. 1374785-50-8
Cat. No. CS-0504390
Purity≥98%
MDL No.None

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N-(((9H-fluoren-9-yl)methoxy)carbonyl)-N-hexylglycine|CS-0504390

Structure of 1374785-50-8

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Description

N-((9H-fluoren-9-yl)methoxy)carbonyl-N-hexylglycine is a bench-stable, moisture-tolerant amino acid derivative featuring a fluorenylmethoxycarbonyl (Fmoc) protecting group and a hexyl side chain. This combination enables efficient incorporation into peptide synthesis workflows while enhancing solubility in organic solvents. The Fmoc moiety facilitates orthogonal deprotection under mild basic conditions, streamlining sequential coupling steps in solid-phase peptide synthesis.

Application

N-(((9H-fluoren-9-yl)methoxy)carbonyl)-N-hexylglycine serves as a versatile protected amino acid building block for peptide synthesis, enabling efficient N-terminal capping and chain elongation. The Fmoc group provides orthogonal deprotection under mild basic conditions, while the N-hexyl side chain offers enhanced lipophilicity and metabolic stability. Its bench-stable nature and compatibility with standard coupling reagents facilitate high-yielding, scalable peptide assembly with minimal epimerization.

General Information

CAS No. 1374785-50-8
Cat. No. CS-0504390
Purity ≥98%
MDL No. None
Storage 4°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₃H₂₇NO₄
Molecular Weight 381.46
Synonym(s) N-α-(9-Fluorenylmethoxycarbonyl)-N-α-hexylglycine
SMILES O=C(O)CN(C(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)CCCCCC

Computational Chemistry Data

TPSA 66.84
LogP 4.9024
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 9

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

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Other Classifications

Life Science Amino Acids and their Derivatives Glycine and derivatives

Chemical Biology Peptide Chemistry Amino Acid Derivatives

Key Words

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N-(((9H-fluoren-9-yl)methoxy)carbonyl)-N-hexylglycine

CAS No. 1374785-50-8

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